Nebenwirkungen gemildert werden konnen. Viele krebskranke Patientinnen haben den Wunsch, zu ihrem Heilungsprozess selbst etwas beitragen zu konnen. Dabei greifen sie oft zu alternativen Therapieverfahren, die uberwiegend uber unspezifische Immunmodulation, antioxidativ oder die Zellmembran stabilisierend wirken. Checkout Your Cart Price. Browse All departments All departments Books 2 Promotions 2.
Ebook Torrent Downloads For Kindle A Comfortable Range Pdf Epub Ibook
Status Available to order 2. Brand Grin Verlag 2. The skin treatment composition according to the invention may contain one or more amphoteric surfactants, advantageously in amounts, based on the total composition, of 0 to 30 wt. According to another preferred embodiment, the compositions of the invention can be free of amphoteric surfactants. In one particular embodiment, the inventive compositions may contain very little total surfactant such. Example, the total surfactant less than 20 wt.
Soluble complexing agent of the invention may be preferably in amounts of 0. Suitable examples are citrates, SKS-6, citric acid, MGDA methyl glycine di-acetic acid , triphosphates, phosphonates, aliphatic dicarboxylic acids eg. As adipic, glutaric, succinic acid. According to another preferred embodiment, the compositions of the invention can be free of soluble complexing agents. Weitere geeignete organische Komplexbildner sind Dextrine, beispielsweise Oligomere bzw. Other suitable organic chelating agents are dextrins, for example oligomers or polymers of carbohydrates which may be obtained by partial hydrolysis of starches.
The hydrolysis can be carried out by customary, for example acid- or enzyme-catalyzed methods. A polysaccharide with a dextrose equivalent DE in the range of 0. Ein bevorzugtes Dextrin ist in der A preferred dextrin is in the britischen Patentanmeldung 94 19 British patent application 94 19 The oxidized derivatives of such dextrins are their reaction products with oxidizing agents which are capable of oxidizing at least one alcohol function of the saccharide ring to the carboxylic acid function.
Auch Oxydisuccinate und andere Derivate von Disuccinaten, vorzugsweise Ethylendiamindisuccinat, sind weitere geeignete Cobuilder. Oxydisuccinates and other derivatives of disuccinates, preferably ethylenediamine, are more suitable co-builders. Weiterhin bevorzugt sind in diesem Zusammenhang auch Glycerindisuccinate und Glycerintrisuccinate. Further preferably in this context, glycerin and glycerol.
Geeignete Einsatzmengen liegen beispielsweise bei 3 bis 15 Gew. The quantities used, for example, at 3 to 15 wt. Other useful organic co-complexing agents are, for example, acetylated hydroxycarboxylic acids and salts thereof, which may optionally be present in lactone form and which contain at least 4 carbon atoms and at least one hydroxyl group and at most two acid groups. Dabei handelt es sich insbesondere um Hydroxyalkan- bzw. Another class of substances with co-complexing properties is the phosphonates.
These are especially hydroxyalkane and aminoalkanephosphonates. Among the hydroxyalkane phosphonates, 1-hydroxyethane-1,1-diphosphonate HEDP is particularly important as a co-complexing agent. Es wird vorzugsweise als Natriumsalz eingesetzt, wobei das Dinatriumsalz neutral und das Tetranatriumsalz alkalisch pH 9 reagiert. It is preferably used as the sodium salt, the disodium neutral reaction and the tetrasodium salt an alkaline reaction pH 9.
Sie werden vorzugsweise in Form der neutral reagierenden Natriumsalze, z. They are preferably in the form of the neutral sodium salts, for. Of the class of phosphonates, HEDP is preferably used as a builder. The aminoalkanephosphonates have a pronounced heavy metal binding capacity. Dementsprechend kann es, insbesondere wenn die Mittel auch Bleiche enthalten, bevorzugt sein, Aminoalkanphosphonate, insbesondere DTPMP, einzusetzen, oder Mischungen aus den genannten Phosphonaten zu verwenden. Accordingly, it may in particular when the agents also contain bleach be preferred aminoalkanephosphonates, in particular, to use DTPMP, or to use mixtures of said phosphonates.
Preferred organic complexing agents are for example usable in the form of their alkali metal and especially sodium salts polycarboxylic acids such as citric acid, adipic acid, succinic acid, glutaric acid, tartaric acid, sugar acids, aminocarboxylic acids, nitrilotriacetic acid NTA , providing their use for environmental reasons, is not objectionable, and mixtures thereof. Preferred salts are the salts of polycarboxylic acids such as citric acid, adipic acid, succinic acid, glutaric acid, tartaric acid, sugar acids and mixtures thereof.
The acids per se can be used. The acids in addition to their complexing effect also typically have the property of an acidifying component and, hence, also serve to establish a relatively low and mild pH value preferred inventive skin treatment agent. Citric acid, succinic acid, adipic acid, gluconic acid and any mixtures thereof are particularly mentioned. Complexing agents INCI Chelating Agents , also known as sequestering agents, are ingredients which are capable of complexing and inactivating metal ions are capable of, for example, their adverse effects on the stability or appearance of the means to prevent, for example opacities.
On the one hand it is very important this include the complexing with numerous ingredients incompatible calcium and magnesium ions of water hardness. The complexing of the ions of heavy metals such as iron or copper delays the oxidative decomposition of the finished compositions.
Preferred complexing agents are tertiary amines, in particular tertiary alkanolamines amino alcohols. Particularly preferred tertiary alkanolamines are triethanolamine and tetraHydroxyPro-pylethylendiamin N, N, N ', N'-tetrakis 2-HydroxyPro-propyl ethylenediamine. Particularly preferred combinations of tertiary amines with zinc ricinoleate and one or more ethoxylated fatty alcohols as nonionic solubilizer as well as optionally solvents are described in the prior art.
A particularly preferred chelating agent is etidronic acid 1-hydroxyethylidene-1,1-diphosphonic acid, 1-Hydroxyethyan-1,1-diphosphonic acid, HEDP, acetophosphonic, INCI Etidronic Acid , including their salts. The inventive composition preferably contains at least one complexing agent in a total amount of usually 0 to 20 wt.
Es sei an dieser Stelle darauf hingewiesen, dass sich die Angabe Gew. It should be noted at this point that the percentages by. The content of water in the preferred agents of the invention depends, inter alia on whether the composition is in liquid or solid form, therefore, is preferably from 0 to less than wt. In the case of liquid agent composition of the invention includes according to a preferred embodiment, water in an amount of more than 20 wt. Die Obergrenze an Wasser kann auch bei 80 Gew. The upper limit of water can also at 80 wt.
Die Untergrenze an Wasser kann z. The lower limit of water z can. The upper and lower limits mentioned can be usefully combined, of course, for. If composition of the invention in particulate form, for example as anti-acne powder, or as a matting powder, so the particles can be post-treated, for example by rounding the particles of the agent. The rounding can be done in a conventional rounder. Verrundungszeiten von maximal 1,5 Minuten oder darunter sind insbesondere bevorzugt.
Rounding times of not more than 1. Durch die Verrundung wird eine weitere Vereinheitlichung des Kornspektrums erreicht, da gegebenenfalls entstandene Agglomerate zerkleinert werden. By the rounded edges to further standardize the grain spectrum is achieved, since any agglomerates formed are comminuted.
Zubereitungsformen, welche diese Inhaltsstoffe enthalten, vorzugsweise mit Mengen bis zu 20 Gew. In particular, an agent of the invention may also with solids, preferably wt. As solids for post-treatment can preferably be bicarbonate, carbonate, zeolite, silica, citrate, urea or mixtures thereof, in particular in amounts of from 2 to 15 wt.
In a further preferred embodiment, the skin treatment composition of the invention contains at least contain a UV-absorbing substance. Bei einem Einsatz in geringen Mengen bis etwa 1 Gew. When used in small amounts up to about 1 wt. When used in higher amounts from more than 1 wt. Under UV-absorbing substance, organic and inorganic substances light protection filters which are to be understood, that are able to absorb ultraviolet rays in the position and the energy absorbed in the form of longer-wave radiation, for example. In addition, substituted benzotriazoles, 3-phenyl-substituted acrylates cinnamic acid derivatives , optionally with cyano groups in the 2-position, salicylates and natural substances, such as umbelliferone and the body's own urocanic acid.
Das Journal für Mikronährstoff-Forschung
Suitable UV-B absorbers include 3-benzylidene camphor or 3-benzylidene norcamphor and derivatives thereof, for. Butylphenyl 4'methoxyphenyl propan-1,3-dion; B. Sulfonic acid derivatives of 3-benzylidenecamphor, such as. Butylphenyl 4'-methoxyphenyl propan-1,3-dion, 4-tert.
Typical UV-A filters are, in particular, derivatives of benzoylmethane, for example 1- 4'-tert-butylphenyl 4'-methoxyphenyl propane-1,3-dione, 4-tert-butyl -4'-methoxydibenzoylmethane Parsol , 1-phenyl 4'-isopropylphenyl -propane-1,3-dione as well as enamine compounds. Besides the soluble substances mentioned, for this purpose, insoluble light protection pigments, namely finely dispersed, preferably nano metal oxides or salts.
Examples of suitable metal oxides are in particular zinc oxide and titanium dioxide and also oxides of iron, zirconium, silicon, manganese, aluminum and cerium and mixtures thereof. As salts of silicates can be used talc , barium sulfate or zinc stearate. The oxides and salts are used in the form of the pigments for skin-care and skin-protecting emulsions and decorative cosmetics. Die Partikel sollten dabei einen mittleren Durchmesser von weniger als nm, vorzugsweise von 5 bis 50 nm und insbesondere von 15 bis 30 nm aufweisen.
The particles should have a mean diameter of less than nm, preferably from 5 to 50 nm and in particular from 15 to 30 nm. You can have a spherical shape, but it is also such particles are used which have an ellipsoidal or otherwise deviates from the spherical shape. The pigments can also be surface treated, ie be hydrophilicized or hydrophobicized. Typische Beispiele sind gecoatete Titandioxide, wie z.
Typical examples are coated titanium dioxides, for. Als hydrophobe Coatingmittel kommen dabei vor allem Silicone und dabei speziell Trialkoxyoctylsilane oder Simethicone in Frage. As a hydrophobic coating materials are, above all, silicones and particularly trialkoxyoctylsilanes or simethicone eligible. Ebenfalls bevorzugt kann mikronisiertes Zinkoxid verwendet werden. Also preferably micronized zinc oxide can be used. Further suitable UV photoprotective filters can be found in the relevant prior art. The at least one UV-absorbing substance is in preferred inventive skin treatment agents in a total amount of 0.
These quantities include the photocatalytically active metal oxide, at least one used in the invention, which can also absorb in the UV region, not a. In a further preferred embodiment, the inventive compositions are in liquid form. To achieve a liquid consistency, the use of both liquid organic solvent, and also be advisable to water. Preferred inventive compositions therefore optionally contain at least one solvent. Solvents which may be used in preferred inventive compositions, for example come from the group of mono- or polyhydric alcohols, alkanolamines or glycolethers providing they are miscible with water in the concentration range.
Preferably, the solvents are selected from ethanol, n- or i-propanol, butanols, glycol, propane or butanediol, glycerol, Diglyol, propyl or butyl diglycol, hexylene glycol, ethylene glycol methyl ether, ethylene glycol ethyl ether, ethylene glycolpropylether, ethylene glycol mono-n-butyl ether, diethylene glycol methyl ether, diethylene glycol ethyl ether, Propylenglycolmethyl-, ethyl or propyl ether, butoxy-propoxy-propanol BPP , Dipropylenglycolmonomethyl-, or ethyl ether, di-isopropylene glycol monomethyl or monoethyl ether, methoxy, ethoxy or butoxytriglycol, 1-butoxyethoxypropanol, 3-methylmethoxybutanol, propylene glycol t-butyl ether and mixtures of these solvents.
The choice of glycol ether can be easily made by the skilled person on the basis of its volatility, water solubility, its percentage by weight of the total dispersion and the like. Pyrrolidone solvent such as N-alkylpyrrolidones, for example N-methylpyrrolidone or NC 8 -C 12 -alkyl-pyrrolidone, or 2-pyrrolidone, may also be employed. Further preferably, as sole solvent or as a component of a solvent mixture are glycerol derivatives, in particular glycerol.
Among the alcohols which can be preferably used in the present invention as co-solvents include liquid polyethylene glycols, lower molecular weight, for example polyethylene glycols having a molecular weight of , , or Other suitable cosolvents include other alcohols, for example a lower alcohols such as ethanol, propanol, isopropanol and n-butanol, b ketones such as acetone and methyl ethyl ketone, c C 2 -C 4 polyols such as a diol or a triol, such as ethylene glycol, propylene glycol, glycerol or mixtures thereof.
Insbesondere bevorzugt ist aus der Klasse der Diole 1,2-Octandiol. Particularly preferred is from the class of the diols 1,2-octanediol. The inventive C 3 - to C 12 glycol ethers contain alkyl or alkenyl groups with less than 10 carbon atoms, preferably up to 8, especially up to 6, particularly preferably 1 to 4 and most preferably 2 to 3 carbon atoms. Preferred C 1 - to C 4 monoalcohols are ethanol, n-propanol, iso-propanol and tert-butanol.
Preferred C 2 - to C 6 glycols are ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,5-pentanediol, neopentyl glycol and 1,6-hexanediol, in particular ethylene glycol and 1,2-propylene glycol. Preferred agents contain one or more solvents in a total amount of usually up to 90 wt. In a further preferred embodiment, the inventive agent comprises at least one viscosity regulator, which preferably acts as a thickener. The viscosity of the compositions of the invention can be measured using standard methods e.
Preferred liquid to gel-like compositions have viscosities from 20 to mPas, from 40 to mPas are particularly preferred. Geeignete Verdicker sind anorganische oder polymere organische Verbindungen. Suitable thickeners are inorganic or polymeric organic compounds.
- Technology general issues;
- FOLK TALES FROM MY NECK OF THE WOODS.
- Special offers and product promotions.
- Product details?
It can also be used mixtures of two or more thickeners. The inorganic thickeners include, for example, polysilicic acids, mineral clays like montmorillonite, zeolites, silicas, aluminum silicates, phyllosilicates and bentonites. The organic thickeners belong to the groups of natural polymers, modified natural polymers and fully synthetic polymers. From nature-derived polymers which are used as thickeners, are Exemplified as xanthan gum, agar agar, carrageen, tragacanth, gum arabic, alginates, pectins, polyoses, guar gum, gellan gum, locust bean flour, starch, dextrins, gelatins and casein.
Modified natural substances originate primarily from the group of modified starches and celluloses, examples here carboxymethyl cellulose and other cellulose ethers, hydroxyethyl and hydroxypropyl cellulose, highly etherified methylhydroxyethylcellulose and gum ethers may be mentioned. A large group of thickeners, which are widely used in various application fields, the fully synthetic polymers such as polyacrylic and polymethacrylic compounds, which may be crosslinked or uncrosslinked and optionally cationically modified vinyl polymers, polycarboxylic acids, polyethers, activated polyamide derivatives, castor oil derivatives, polyimines, polyamides and polyurethanes.
Examples of such polymers are acrylic resins, ethyl acrylate acrylamide copolymers, acrylate-methacrylic acid ester copolymers, ethyl acrylate-acrylic acid-methacrylic acid copolymers, N-Methylolmeth-acrylamide, maleic anhydride-methyl vinyl ether copolymers, polyether polyol copolymers and butadiene -styrene copolymers. Other suitable thickeners are derivatives of organic acids and their alkoxide adducts, for example aryl polyglycol ether, carboxylated Nonylphenolethoxylatderivate, sodium alginate, diglycerol monoisostearate, Nonionic ethylene oxide adducts, coconut fatty acid diethanolamide, isododecenyl succinic anhydride as well as galactomannan.
Dyes can optionally be used in the inventive agent, wherein the amount or more dyes should be selected so low at a that after the application of the agent no visible residues remain. Preferably, the compositions according to the invention is free of dyes. The inventive composition may preferably be one or more antimicrobial agents or preservatives in an amount of usually 0. Konservierungsmittel unterscheidet man je nach antimikrobiellem Spektrum und Wirkungsmechanismus zwischen Bakteriostatika und Bakteriziden, Fungistatika und Fungiziden usw.
Wichtige Stoffe aus diesen Gruppen sind beispielsweise Benzalkoniumchloride, Alkylarylsulfonate, Halogenphenole und Phenolmercuriacetat. Antimicrobial agents or preservatives are differentiated, depending on the antimicrobial spectrum and mechanism of bacteriostatic agents and bactericides, fungistatic agents and fungicides, etc. Important substances from these groups are, for example, benzalkonium chlorides, alkylarylsulfonates, halogen phenols, and phenol.
The terms antimicrobial action and antimicrobial active ingredient have the context of the inventive teaching usual meaning. Furthermore, halogenated xylene and cresol, such as p-Chlormetakresol or p-chlorometaxylene, and natural antimicrobial active ingredients of plant origin eg. As of spices or herbs , animal and microbial origin are. Substances of microbial origin, so-called bacteriocins can be used. Glycine, glycine, formaldehyde, compounds which easily split off formaldehyde, formic acid and peroxides are used preferably.
The suitable as antimicrobial agents quaternary ammonium compounds QAC have already been described above. Besonders geeignet ist beispielsweise Benzalkoniumchlorid etc. Is particularly suitable, for example, benzalkonium chloride, etc. Further preferred compositions according to the invention are characterized in that the at least one alkyl or hydroxyalkyl-substituted urea of the general formula is selected A consists of compounds in which R 1, R 2, R 3 and R 4 independently represent a hydrogen atom, a methyl , ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert.
Butyl, or C 2 -C 6 hydroxyalkyl group, which is substituted by 1 to 5 hydroxyl groups or C 1 -C 4 hydroxyalkyl groups are, with the proviso that at least one of the radicals R 1 and R 2 and at the same at least one of the radicals R 3 and R 4 is a C 2 -C 6 hydroxyalkyl group, which is substituted by 1 to 5 hydroxyl groups or C 1 -C 4 hydroxyalkyl groups representing.
Particularly preferred are lysine, serine, N-acetyl-L-cysteine, zinc and sodium pyroglutamate and sodium lauroyl glutamate. The C 2 -C 24 acyl group, with the said amino acids are derivatized at the amino group is selected from acetyl, propanoyl, butanoyl, pentanoyl, hexanoyl, heptanoyl, octanoyl, nonanoyl, decanoyl , undecanoyl, lauroyl, tridecanoyl, myristoyl, pentadecanoyl, Cetoyl-, palmitoyl, stearoyl, Elaidoyl-, Arachidoyl- or behenoyl radical. Mischungen von C 8 -C 18 -Acylresten werden auch als Cocoyl-Rest bezeichnet und sind ebenfalls bevorzugte Substituenten.
Mixtures of C 8 -C 18 acyl radicals are also referred to as a cocoyl radical and are also preferred substituents. With the aforementioned C 2 -C 24 acyl radicals, the amino acids which carry an OH group can also be esterified at this OH group.
- God With Us … Visits Us (The Word of God Encyclopedia Book 2);
- Fourier Series PDF?
- So Youre Left Behind ... Surviving the Rapture and Other Apocalypse Scenarios.
- Boulimie-Anorexie - Guide de survie pour vous et vos proches - 2e éd. (Mieux vivre) (French Edition).
An inventively preferred example is hydroxyproline, which is N-acylated with two, preferably linear C 2 -C 22 fatty acid residues esterified and, particularly preferably dipalmitoyl hydroxyproline, the z. The substitution of Gly Ala, Leu and Ile are suitable for the invention. The inventively preferred amino acids that can replace His or Lys contain a side chain having a nitrogen atom mainly charged is present at pH 6, z.
Pro, Lys, Arg, His, and desmosin isodesmosine. Besonders bevorzugt wird Lys durch Arg, Orn, oder Citrullin ersetzt. Lys is particularly preferably replaced by Arg, Orn or citrulline. Tripeptide-3 and its derivative, N-myristoyl-Gly-His-Arg, the z. Rigin has the sequence Gly-Gln-Pro-Arg. Rigin-based tetrapeptides include rigin rigin analogs and derivatives, in particular in the present invention, particularly preferred N-palmitoyl-Gly-Gln-Pro-Arg, the z. As is available under the designation Eyeliss from Sederma, but also represents a part of the product Matrixyl of Sederma.
For example, the sequence Ala-Gln-Thr-Arg. Preferably, at least one of the amino acids of the sequence has a Pro or Arg, and most preferably, the tetrapeptide includes both Pro and Arg, which can vary their order and position. The substituting amino acids can be selected from any amino acid which is defined below. Besonders bevorzugte Rigin-basierte Tetrapetide umfassen: Particularly preferred rigin-based Tetrapetide include: The preferred amino acids can replace Gly include an aliphatic side chain, eg. The preferred amino acids can replace Gln contain a side chain having an amino group at neutral pH pH is predominantly uncharged, z.
Asn, Lys, Orn, 5-hydroxyproline, Citrulline and canavanine. The preferred amino acids can replace Arg contain a side chain having a nitrogen atom mainly charged is present at pH 6, z. Pro, Lys, His, Desmosin und Isodesmosin. Pro, Lys, His, desmosin and isodesmosine. Gln, Asn, Lys, Orn, 5-hydroxyproline, Citrulline and canavanine. Furthermore ALAMCAT tetrapeptides include at least one amino acid having a side chain having a nitrogen atom present in predominantly charged at pH 6, z.
Arg, Pro, Lys, His, desmosin and isodesmosine. TPI , Hexapeptide-5 z. Collaxyl von Vincience und Hexapeptide z. Modulene von Vincience , Acetyl Glutamyl Hexapeptide-1 z. Collasyn 6ks of Therapeutic peptides Inc. Collasyn 6ks of TPI , myristoyl Hexapeptide-8 z. Collaxyl of Vincience and Hexapeptide z. Modulene of Vincience , acetyl Hexapeptide-glutamyl 1 z. Collaxyl von Vincience , Hexapeptide z. Collaxyl von Vincience oder Seriseline von Lipotec und Hexapeptide z.
Peptamide-6 von Arch Personal Care. Collasyn 6ks of Therapeutic Peptides Inc. Collaxyl of Vincience Hexapeptide e. Collaxyl of Vincience or Seriseline of Lipotec and Hexapeptide z. Peptamide-6 from Arch personal Care. An inventively preferred pentadecapeptide z. As the raw material Vinci 01 by Vincience pentadecapeptides According to the invention particularly preferred is the combination of N-palmitoyl-Gly-His-Lys and N-palmitoyl-Gly-Gln-Pro-Arg, such as is sold by the company Sederma, for example in the raw material Matrixyl th.
Tierische Proteinhydrolysate sind z. Animal protein hydrolysates are for. As elastin, collagen, keratin, silk, Conchiolin- and may also be in the form of salts milk protein hydrolysates. According to the invention plant protein, z are. As soy, wheat, almond, pea, potato and rice protein hydrolysates. Entsprechende Handelsprodukte sind z. Corresponding commercial products are,. Besonders bevorzugt sind Sojaproteinhydrolysate, besonders bevorzugt Sojaproteinhydrolysate mit einem mittleren Molekulargewicht im Bereich von Dalton, bevorzugt im Bereich von Dalton, z.
Particularly preferred are soy protein hydrolysates, particularly preferably soy protein hydrolysates with an average molecular weight in the range of daltons, preferably in the range of daltons, z. Coconut fatty acids comprise predominantly alkanecarboxylic acids having a number of carbon atoms of , in particular caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid and stearic acid.
Preferred alkali metal salts are selected from lithium, sodium and potassium salts, the potassium salts are particularly preferred. Furthermore, according to the invention are preferably keratin, in particular Wollkeratinhydrolysate. A particularly preferred Wollkeratinhydrolysat is available under the name Pep Keratec by Croda. Keratec Pep has a smaller molecular weight fraction having an average molecular weight of daltons and a larger molecular weight fraction having an average molecular weight of daltons.
Furthermore, according to the invention are preferably Conchiolinhydrolysate, in particular those which Pearl Protein Extract and Pearl Protein Extract BG by the company Maruzen are available under the names. Conchiolin is a complex protein that is produced from the outer epithelium of molluscs, especially oysters and various species of snails and forming the very stable shell of these mollusks by incorporation of calcium carbonate crystals.
Ebenfalls bevorzugt ist der Einsatz von Acylderivaten der Proteinhydrolysate, z. Also preferred is the use of acyl derivatives of protein hydrolysates, z. Another preferred active ingredient according to the invention, the effect in the presence of the photocatalytically active metal oxide used in the invention, improved is the peptide derivative L-Glutamylaminoethyl-indole obtainable, for. Example, under the trade name of Glistin Exsymol.
According to the invention and cationized protein are. Besondes bevorzugt sind kationische Proteinhydrolysate, deren zugrunde liegender Proteinanteil ein Molekulargewicht von bis zu Dalton, bevorzugt bis Dalton aufweist. Besondes preferred are cationic protein hydrolyzates in which the underlying protein fraction has a molecular weight of to 25, daltons, preferably to daltons.
Quaternized amino acids and mixtures thereof are to be understood as cationic protein. The cationic protein hydrolysates can also be further derivatized. Ganz besonders bevorzugt sind die kationischen Proteinhydrolysate und -derivate auf pflanzlicher Basis. Most preferably, the cationic protein hydrolysates and derivatives based on plants.
In a further preferred embodiment, the polymers of the amino acids are selected from DNA repair enzymes. These two enzymes are known in the prior art already known as DNA repair enzymes. Photolyase is the abbreviation for deoxyribodipyrimidine photolyase or DNA photolyase, an enzyme with the classification number EC 4. Eine besonders effiziente Photolyase stammt aus Anacystis nidulans, einem phototrophen marinen Mikroorganismus.
A particularly efficient Photolyase comes from Anacystis nidulans, a phototrophic marine microorganism. Die Photolyase aus A. The Photolyase from A. Photolyase ist zur Aktivierung auf Licht angewiesen. Photolyase is dependent on light for activation. The enzyme T4 endonuclease V is produced by the denV gene of bacteriophage T4 and is one of the phosphodiesterases, which the nucleic acids of the 5'-3 ' - column bond hydrolysis. T4N5 ist auch ohne Lichteinfluss aktiv. T4N5 is active even without the influence of light.
According to the invention particularly preferred is the use of liposome-encapsulated DNA repair enzymes. Liposomenverkapselte Photolyase ist im Handel z. Liposome-encapsulated Photolyase is commercially z. According to the invention, particularly preferred compositions are characterized in that they in total amounts of from 0. In a further preferred embodiment, the compositions of the invention contain at least one DNA oligonucleotide or at least one RNA oligonucleotide. According to the invention under an oligonucleotide polymers of 2 to 20, preferably 2 to 10 mononucleotides understood that are equally as with polynucleotides and nucleic acids linked by phosphoric acid diester bridges.
The mononucleotides are, for example, adenosine phosphate, cytidine, guanosine, and Uridinphosphate Thymidinphosphate, especially CMP cytidine-5'-monophosphate , UDP uridine 5'-diphosphate , ATP adenosine-5'-triphosphate and GTP guanosine 5'-triphosphate. An inventively particularly preferred oligonucleotide is the thymidine dinucleotide. In another preferred embodiment, the inventive compositions comprise at least one natural betaine compound. So-called betaine synthetic not covered by the invention, used according to betaine compounds, nor other zwitterionic compounds in which the positive charge on N or P and the negative charge is formally O, S, B or C, but not the IUPAC rule C According to the invention, particularly preferred compositions are characterized in that they preferably at least one natural betaine compound in a total amount of 0.
In a further preferred embodiment, the compositions of the invention contain at least one vitamin, provitamin or designated as a vitamin precursor compound from the vitamin groups A, B, C, E, H and K and esters of the aforementioned substances. The group of substances designated as vitamin A include retinol vitamin A 1 and 3,4-didehydroretinol vitamin A 2. As vitamin A component according to the invention are particularly preferably vitamin A acid and its esters, vitamin A aldehyde, and Vitamin A alcohol and its esters, such as retinyl palmitate and retinyl acetate.
According to the invention, particularly preferred compositions are characterized in that they preferably, in addition to the used in the invention photocatalytically active metal oxide, at least one vitamin, provitamin or designated as a vitamin precursor compound from the group of vitamins A or at least one ester thereof in total amounts of from 0.
Particularly preferred are the 2-furanone derivatives in which the substituents R 1 to R 6 independently represent a hydrogen atom, a hydroxyl radical, a methyl, methoxy, aminomethyl or hydroxymethyl radical, a saturated or mono- or di-unsaturated, linear or branched C 2 -C 4 hydrocarbon radical, a saturated or mono- or diunsaturated, branched or linear mono-, di- or trihydroxy-C 2 -C 4 hydrocarbon radical or a saturated or mono- or diunsaturated, branched or linear mono- represent, di- or triamino-C 2 -C 4 -hydrocarbon -.
The present invention exceptionally preferred 2-furanone derivative is pantolactone dihydrohydroxy-4,4-dimethyl-2 3H -furanone , wherein in formula I R 1 represents a hydroxyl group, R 2 represents a hydrogen atom, R 3 and R 4 represent a hydrogen atom, a methyl group and R 5 and R. The stereoisomer R -pantolactone formed during the degradation of pantothenic acid.
According to the invention, particularly preferred compositions are characterized in that they B 5 type as well as the 2-furanone derivatives in a total amount of 0. In a further preferred embodiment, the compositions of the invention contain at least one substance selected from vitamins, provitamins and vitamin precursors of the group B 1, B 2, B 3, B 6, B 7, B 9, B 13, and their esters, and from pantolactone. Preferred vitamins, provitamins and vitamin precursors of the group C and the esters thereof are vitamin C ascorbic acid and the derivatives ascorbyl palmitate, stearate, palmitate, acetate, magnesium ascorbyl phosphate, sodium ascorbyl phosphate, sodium and magnesium ascorbate, Dinatriumascorbylphosphat and sulfate, Kaliumascorbyltocopherylphosphat, or Chitosanascorbat ascorbyl.
Die Kombination mit Tocopherolen kann ebenfalls bevorzugt sein. The combination with tocopherols can likewise be preferred. Nutrition and Cancer 3: Gleichzeitig liefert Soja-Protein wertvolle Soja-Isoflavone.
Technology general issues | All Books Download Free.
Dieser Mechanismus bringt eine ganze Reihe an positiven, regulierenden Effekten mit sich: Hierbei kommt dem Isoflavon Genistein eine entscheidende Rolle zu: Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet. Am J Clin Nutr ; The effect of dietary soy supplementation on hot flushes. Meta-analysis of the effects of soy protein intake on serum lipids.
N Engl J Med ; Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. The role of phytoestrogens in the prevention and treatment of osteoporosis in ovarian hormone deficiency. J Am Coll Nutr. A, Juma S, Payton M. Soy protein has a greater effect on bone in postmenopausal women not on hormone replacement therapy, as evidenced by reducing bone resorption and urinary calcium excretion.
Do soy isoflavones lower cholesterol, inhibit atherosclerosis, and play a role in cancer prevention? Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women. J Clin Endocrinol Metab ; Balancing safety and efficacy focus on endometrial protection. J Reprod Med ; Beneficial role of dietary phytoestrogens in obesity and diabetes.
American Journal of Clinical Nutrition. Review of clinical studies on cholesterol-lowering response to soy protein. J Am Diet Assoc ; Biological effects of a diet of soy protein rich in isoflavone on the menstrual cycle of premenopausal women. The potential of soybean phytoestrogens for postmenopausal hormone replacement therapy. Proc Soc Exp Biol Med ; Superoxide-mediated actin response in post-hypoxic endothelial cells. J Biol Chem ; Modest hormonal effects of soy isoflavones in postmenopausal women. Reduced mortality associated with long-term postmeno-pausal estrogen therapy. Physiology of hot flashes.
Am J Human Biol ; Accessed May 6, A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy. Arch Intern Med ; The cardiovascular effects of soy products. Reproductive and general metabolic effects of phytoestrogens in mammals. Hormonal effects of soy isoflavones: Studies in premenopausal and postmenopausal women. J Nutr ; New England Journal of Medicine, , — Its estrogenic effects may protect women.
Phytoestrogen interaction with estrogen receptors in human breast cancer cells. Medical nutrition and disease 2nd ed. Dietary flour supplementation decreases post-menopausal hot flushes: Effect of soy and wheat. Messina M, Hughes C.: Efficacy of soyfoods and soybean isoflavone supplements for alleviating menopausal symptoms is positively related to initial hot flush frequency.
Effects of genistein and hormone-replacement therapy on bone loss in early postmenopausal women: J Bone Miner Res. Dietary isoflavones affect sex hormone-binding globulin levels in postmenopausal women. Soy protein and isoflavones: Soy protein and serum lipids. Curr Opin Lipidol ;7: Overview of proposed mechanisms for the hypocholesterolemic effect of soy. Evaluation of soy phytoestrogens for the treatment of hot flashes in breast cancer survivors: J Clin Oncol ; The effect of the phytoestrogen genistein on plasma nitric oxide concentrations, endothelin-1 levels and endothelium dependent vasodilation in in postmenopausal women.
Clinical effects of a standardized soy extract in postmeonpausal women: Absorption and metabolism of isoflavones. Phytoestrogens after breast cancer. Endocr Relat Cancer ;8: Timing of amino acid ingestion alters anabolic response of muscle to resistance exercise. Am J Endocrinol Metab Effect of soybean phytoestrogen intake on low density lipoprotein oxidation resistance. Practical aspects of hormone replacement therapy. Prog Cardiovasc Dis ; Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: A multicenter, double-blind, randomized, placebo-controlled study.
Actions of progestins on the morphology and biochemistry of the endometrium of postmenopausal women receiving low-dose estrogen therapy. Am J Obstet Gynecol ; Antioxidant and antipromotional effects of the soybean isoflavone genistein. Rotklee wird seit Jahrhunderten als Naturheilmittel eingesetzt. Das Besondere an Rotklee: Randomized, placebo-controlled trial of an isoflavone supplement and menopausal symptoms in women. Use of a mammalian cell culture benzo a pyrene metabolism assay for the detection of potential anticarcinogens from natural products: Inhibition of metabolism by biochanin A, anisoflavone from Trifolium pratense L.
Red clover monograph, a monograph in the series The Review of Natural Products. Facts and Comparisons; Geller SE, Studee L.: